Edible Vomit is all about drug use and drug addiction. The protagonist is a drug addict named Freddy who seeks the "perfect drug". He opens the game by taking methamphetamine (referred to by the less common term "methadrine") that may have been "laced" (purposefully tainted) and then suffering a bad "trip" (drug-induced hallucination) that persists throughout the game. The text and graphics for this scene explicitly depict him using a syringe to inject his meth into his veins, complete with using a strap to make his veins easier to find. A later scene depicts him snorting an object through a straw as if it were cocaine. He meets other drug addicts during the game, which include a child addicted to marijuana who wastes away without it, a homeless person who spent all their money on drugs, and a heroin addict on the verge of death. The story ends with Freddy, having finally met the dealer who has the "perfect drug", having a change of heart and giving up drugs because he has seen and experienced the pain and suffering that addiction can cause. He resolves to stay clean from now on, regardless of the damage his addiction has done to him.
The world also has adult content unrelated to drugs; this includes strong profanity and abstract depictions of blood and gore.
